Seroprevalence of HHV-8, CMV, and EBV among the general population in Ghana, West Africa

August 19th, 2008 by admin

Background:
Human herpesvirus 8 (HHV-8), herpes (CMV) and Epstein-Barr virus (EBV) are current in Africa, but inferior ordinary elsewhere and the modes of sending are ease person to debate. Generally, they rarely drive disease in the immunocompetent patron but are highly oncogenic when related with immunosuppression. Although the broad figure of HHV-8, herpes and herpes has been substantially registered in Africa, much accumulation are distributed from Ghana.
Methods:
Serum samples from 3275 HIV-seronegative flourishing murder donors and 250 HIV-AIDS patients were proven for antibodies limited for HHV-8, herpes and herpes by immunoglobulin assay assays. Differences in seropositivity rates by sexuality and geezerhood were evaluated using the Chi-square effort with Yates correction.
Results:
Of the 3275 HIV-seronegative flourishing murder donors tested, 2573 (78.6%) were males and 702 (21.4%) were females, with ages ranging from 18 to 65 eld (median 32.6; stingy 31.2; fashion 30). Of the 250 HIV-AIDS patients tested, 140 (56%) were males and 110 (44%) were females, with ages ranging from 17 to 64 eld (median 30.8; stingy 30.3; fashion 28). Among the HIV-seronegative flourishing murder donors, coverall seroprevalence of HHV-8, herpes and herpes was 23.7%, 77.6% and 20.0%, respectively. Among the HIV-AIDS patients, coverall seroprevalence of HHV-8, herpes and herpes was 65.6%, 59.2% and 87.2%, respectively. The seroprevalence of HHV-8 (p < 0.005) and herpes (p < 0.001) was statistically significantly higher in HIV-AIDS patients compared to HIV-seronegative flourishing murder donors. There was no statistically momentous disagreement (p = 0.24) between herpes seroprevalence in HIV-AIDS patients and HIV-seronegative flourishing murder donors. Age and sexuality were not autarkical determinants (p > 0.05) for every threesome infections among HIV-seronegative flourishing murder donors and HIV-AIDS patients in Ghana.
Conclusions:
The results presented herein inform that HHV-8, herpes and herpes infections are hyperendemic in both HIV-seronegative and HIV-seropositive Ghanaians, and declare primarily a flat line of sending of these threesome viral infections in Ghana.

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