Healthcare-associated infections in pediatric cancer patients: results of a prospective surveillance study from university hospitals in Germany and Switzerland

May 26th, 2008 by admin

Background:
Pediatric cancer patients grappling an accumulated venture of healthcare-associated incident (HAI). To date, no likely multicenter studies hit been publicised on this topic.
Methods:
Prospective multicenter surveillance for HAI and nosocomial feverishness of uncharted lineage (nFUO) with limited housing definitions and standard surveillance methods.
Results:
7 medicine oncology centers (university facilities) participated from Apr 01, 2001 to August 31, 2005. During 54,824 life of patient surveillance, 727 HAIs and nFUOs were qualified in 411 patients. Of these, 263 (36%) were HAIs in 181 patients, for an frequency spacing (ID) (number of events per 1,000 patient days) of 4.8 (95% CI 4.2 to 5.4; arrange 2.4 to 11.7; P < 0.001), and 464 (64%) were nFUO in 230 patients. Neutropenia at identification correlated significantly with clinical rigor of HAI. Of the 263 HAIs, 153 (58%) were bloodstream infections (BSI). Of the 138 laboratory-confirmed BSIs, 123 (89%) were attendant with ingest of a long-term bicentric venous catheter (CVAD), resulting in an coverall ID of 2.8 per 1,000 utilization life (95% CI 2.3 to 3.3). The ID was significantly modify in Port-type than in Hickman-type CVADs. The modification of 8 children was attendant to HAI, including sextet cases of aspergillosis. The imputable mortality was 3.0% without a momentous connexion to neutropenia at instance of NI diagnosis.
Conclusions:
Our think addicted that medicine cancer patients are at an accumulated venture for limited HAIs. The likely surveillance of HAI and comparability with additive multicenter results are vital for targeted hindrance of these inauspicious events of antitumor treatment.

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