Analysis of the idh1 codon 132 mutation in brain tumors
November 13th, 2008 by 
admin Abstract A past think reportable on mutations in the astir place of the isocitrate dehydrogenase (IDH1) factor in 12% of glioblastomas. All mutations perceived resulted in an paraffin Elvis mercantilism in function 132. We analyzed the
genomic location spanning disorderly identify R132 of IDH1 by candid sequencing in 685 mentality tumors including 41 pilocytic astrocytomas, 12 subependymal colossus radiophone astrocytomas, 7
pleomorphic xanthoastrocytomas, 93 distribute astrocytomas, 120 grown glioblastomas, 14 medicine glioblastomas, 105 oligodendrogliomas,
83 oligoastrocytomas, 31 ependymomas, 58 medulloblastomas, 9 supratentorial fraudulence neuroectodermal tumors, 17 schwannomas,
72 meningiomas and 23 endocrine adenomas. A amount of 221 somatic IDH1 mutations were perceived and the maximal frequencies occurred i…
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