IL-21 stimulates manlike myeloma radiophone ontogeny finished an autocrine IGF-1 loop.
J Immunol. 2008 Nov 15;181(10):6837-42
Authors: Ménoret E, Maïga S, Descamps G, Pellat-Deceunynck C, Fraslon C, Cappellano M, Moreau P, Bataille R, Amiot M
IL-21 is a member of the identify I cytokine kinsfolk attendant most intimately to IL-2 and IL-15. IL-21 is a pleiotropic cytokine, produced by T, NKT, and dendritic cells, which modulates lymphoid and myeloid radiophone functions. Besides its activities on connatural lymphoid cells, it has been shown that IL-21 is a ontogeny bourgeois for myeloma cells. In the inform study, we shew that IL-21 generated myeloma colonies from 9 of 24 manlike myeloma radiophone lines (HMCL) in a collagen-based assay. Of field interest, the power of IL-21 to impact clonogenicity …