p53 and Pten curb neuronal and glioma stem/progenitor radiophone restoration and differentiation

Nature 455, 1129 (2008). doi:10.1038/nature07443

Authors: Hongwu Zheng, Haoqiang Ying, Haiyan Yan, Alec C. Kimmelman, king J. Hiller, An-Jou Chen, prophet R. Perry, Giovanni Tonon, Gerald C. Chu, Zhihu Ding, Jayne M. Stommel, Katherine L. Dunn, Ruprecht Wiedemeyer, Mingjian J. You, Cameron Brennan, Y. Alan Wang, Keith L. Ligon, Wing H. Wong, Lynda Chin
& Ronald A. DePinho
Glioblastoma (GBM) is a highly fatal mentality growth presenting as digit of digit subtypes with crisp clinical histories and molecular profiles. The direct GBM subtype presents acutely as a high-grade disease that typically harbours mutations in EGFR, PTEN and INK4A/ARF (also famous as CDKN2A), and the alternative GBM subtype evolves …

Tags: Brain, glioma