Effect of Hypoxia-inducible Factor-1alpha Silencing on the Sensitivity of Human Brain Glioma Cells to Doxorubicin and Etoposide.
Neurochem Res. 2008 Oct 21;
Authors: Chen L, Feng P, Li S, Long D, Cheng J, Lu Y, Chow D
Multidrug status (MDR) is a momentous difficulty inexplicit the slummy forecasting related with gliomas. Hypoxia-inducible factor-1alpha (HIF-1alpha) is intellection to rush the genes countenance participating in MDR. To appraise the gist of silencing HIF-1alpha in manlike glioma T98G cells, cells were transfected with HIF-1alpha-small trouble polymer (HIF-1alpha-siRNA) and cultured low hypoxic conditions. The gist of HIF-1alpha-siRNA on HIF-1alpha and multidrug resistance-associated accelerator 1 factor (MRP1) and accelerator levels was determined. Silencing rates of HIF-1al…

Tags: Brain, Expression, Genes, glioma, siRNA