THE CAP SUPERFAMILY: CYSTEINE-RICH SECRETORY PROTEINS, ANTIGEN 5 AND PATHOGENESIS-RELATED 1 PROTEINS - ROLES IN REPRODUCTION, CANCER AND IMMUNE DEFENSE.

Endocr Rev. 2008 Sep 29;

Authors: chemist GM, Roelants K, O’Bryan MK

The cysteine-rich secretory proteins, antigen 5 and pathogenesis-related 1 proteins (CAP) superfamily members are institute in a important arrange of organisms spanning apiece of the birdlike kingdoms. Within humans and mice there are 31 and 33 individualist kinsfolk members respectively, and though some are poorly characterized, the eld exhibit a celebrity countenance partiality to the reproductive tract, insusceptible tissues or are deregulated in cancers. CAP superfamily proteins are most ofttimes secreted and hit an extracellular secretor or paracrine duty and are participating in processes including the conception of extracellular matrix, forking morphogenesis, potentially as either proteases or enzyme inhibitors; in ion steer conception in fertility; as growth cistron or pro-oncogenic genes in tissues including the prostate; and in cell-cell bond during fertilization. This analyse describes mammalian CAP superfamily factor countenance profiles, phylogenetic relationships, accelerator structural properties and natural functions and draws into pore their possibleness persona in upbeat and disease. The figure subfamilies of the mammalian CAP superfamily include: the manlike glioma pathogenesis-related 1 (GLIPR1), histologist related pathogenesis related-1 (GAPR1) proteins, enzyme inhibitor 15 (PI15), enzyme inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL field containing 1 (CRISPLD1), CRISP LCCL field containing 2 (CRISPLD2), mannose organ same and the R3H field containing same proteins. We hold that coverall accelerator structural advance within the CAP superfamily results in essentially kindred functions for the CAP field in every members, still the heterogeneity right of this set location dramatically alters direct specificity, and therefore, the natural consequences.

PMID: 18824526 [PubMed - as supplied by publisher]

(Source: ENDOCR REV)

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Tags: Cancer, Expression, Focus, gene expression, Genes, glioma, Health, Mice, Tissues