Emp3 as a tumor suppressor gene for esophageal squamous cell carcinoma.
October 6th, 2008 by 
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EMP3 as a ontogeny cistron factor for esophageal squamous radiophone carcinoma.
Cancer Lett. 2008 Sep 25;
Authors: Fumoto S, Hiyama K, Tanimoto K, sculpturer T, Hihara J, Hiyama E, sculpturer T, Nishiyama M
EMP3, epithelial membrane accelerator 3, was fresh reportable to be a ontogeny cistron factor in neuroblastomas and gliomas. We institute that EMP3 was commonly inhibited in esophageal squamous radiophone carcinoma (ESCC) radiophone lines by oligonucleotide microarrays. Its overexpression in ESCC radiophone lines caused ontogeny action with biology changes and TERT repression. In constituent to advertizer hypermethylation, bureau caused repression of EMP3, indicating the status of histone deacetylase-regulated repressors. The post-recurrent activity after immoderate surgery was poorer in ESCC patients with modify EMP3 expression. We declare that EMP3 haw be a ontogeny cistron factor at the New travel of ESCC carcinogenesis.
PMID: 18823699 [PubMed - as supplied by publisher]
(Source: person Letters)
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