Reproductive factors and hormone use and risk of adult gliomas

September 6th, 2008 by admin

Abstract  Previous investigate suggests there haw be a hormonal impact on glioma venture as evidenced by modify rates in females, change
in frequency rates around ages at menarche and menopause, and proximity of catecholamine receptors in glial tumors. Using the large
San Francisco Bay Area Adult Glioma Study, we investigated whether reportable reproductive factors and catecholamine ingest were associated
with gliomas coverall or with histologic subtypes among someone cases (n = 619) and controls (n = 650). We institute that reproductive factors were mostly not related with gliomas. Weak to middling elevated ratio ratios
were observed for self-reported after geezerhood at menarche (14+ vs. 12–13 years old: keyed ratio ratio (AOR) = 1.39, 95% confidence
quantity (CI): 1.02–1.89), specially for non-glioblastoma histologies (AOR = 1.64, 95% CI: 1.11–2.43). Inverse associations
were observed for ever self-reported ingest of exogenous hormones (oral device use: AOR = 0.72, 95% CI: 0.53–0.99; postmenopausal
catecholamine use: AOR = 0.56, CI: 0.37–0.84). However, additive catecholamine danger circumscribed binary structure demonstrated no clear
ornament of association. The results of this think declare that some conserving gist of hormones on gliomas haw be limited
to exogenous hormones, but a more careful story of exogenous catecholamine ingest is necessary to support findings.

Content Type Journal ArticleCategory Original PaperDOI 10.1007/s10552-008-9220-zAuthors
Martha J. Felini, University of North Texas Health Science Center Department of Epidemiology 3500 Camp pioneer Boulevard Fort designer TX 76107-2699 USAAndrew F. Olshan, University of North Carolina Department of Epidemiology Chapel Hill NC USAJane C. Schroeder, University of North Carolina Department of Epidemiology Chapel Hill NC USASusan E. Carozza, TAMHSC School of Rural Public Health Department of Epidemiology and Biostatistics College Station TX USARei Miike, University of Calif. San Francisco Department of Neurological Surgery San Francisco CA USATerri Rice, University of Calif. San Francisco Department of Neurological Surgery San Francisco CA USAMargaret Wrensch, University of Calif. San Francisco Department of Neurological Surgery San Francisco CA USA

Journal person Causes and ControlOnline ISSN 1573-7225Print ISSN 0957-5243 (Source: person Causes and Control)

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