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Induction of podoplanin by transforming ontogeny factor-beta in manlike fibrosarcoma.

FEBS Lett. 2007 Dec 22;

Authors: Suzuki H, Kato Y, Kaneko MK, Okita Y, Narimatsu H, Kato M

Podoplanin/aggrus is accumulated in tumors and its countenance was related with ontogeny malignancy. Podoplanin on cancer cells serves as a platelet-aggregating factor, which is related with the metastatic potential. However, regulators of podoplanin rest to be determined. Transforming ontogeny factor-beta (TGF-beta) regulates some physical events, including tumorigenesis. Here, we institute that TGF-beta evoked podoplanin in manlike fibrosarcoma HT1080 cells and enhanced the platelet-aggregating-ability of HT1080. TGF-beta identify I organ inhibitor (SB431542) and brief hairpin Smad4 smothered the podoplanin stimulation by TGF-beta. These results declare that TGF-beta is a physical controller of podoplanin in ontogeny cells.

PMID: 18158922 [PubMed - as supplied by publisher]

(Source: FEBS Letters)

Tags: Suzuki