Experience with adjuvant chemotherapy for pseudomyxoma peritonei secondary to mucinous adenocarcinoma of the appendix with oxaliplatin / fluorouracil /leucovorin (FOLFOX4)

November 13th, 2008 by admin

Background:
Pseudomyxoma peritonei (PMP) is a thin information defined by mucinous tumors, disseminated intra-peritoneal implants, and mucinous ascites. So farther its identification relic hard to most clinicians.Case presentationA 55-year-old phallic enduring had suffered from accent start of abdominal discompose and abdominal enlargement for digit period preceding to his admission. Physical communicating revealed compassionateness over the correct modify line of the cavum without distribute hooligan guarding. A super turn of ascites was identified by abdominal computed picturing (CT) scan. Paracentesis showed the attendance of sticky mucinous ascites. He underwent laparotomy low the notion of pseudomyxoma peritonei. There was a aggregation of mucinous ascites, digit appendiceal growth and binary peritoneal implants disseminated from the subphrenic expanse to the recto-vesicle pouch. Pseudomyxoma Peritonei caused by mucinous carcinoma of appendiceal origin, was addicted by histopathology. We performed an redaction of the appendiceal growth compounded with rich irrigation and debridement. After the operation, he conventional 10 cycles of systemic chemotherapy with FOLFOX4 regimen, without limited morbidity. Follow-up of abdominal CT and colonoscopy at post-operative 17 months showed superior salutation without grounds of topical repetition or lateral metastasis. He prefabricated an quiet feat (up to the present) for 21 months after the operation.
Conclusion:
This housing inform emphasizes the doable newborn persona of systemic chemotherapy in the communication of patients with this thin clinical syndrome.

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