Dna alkylation products formed by 1-(2-chloroethyl)-1-nitrosourea as molecular dosimeters of therapeutic response
November 6th, 2008 by 
admin This think has investigated if individualist polymer adducts bacilliform in manlike glioma cells aerated with 3H-1-(2-chloroethyl)-1-nitrosourea (3H-CNU) could be utilised as molecular dosimeters of salutation after CENU treatment. The levels of individualist polymer alkylation products
were compared with the stimulation of cytotoxicity in sextet manlike glioma radiophone lines after communication with 3H-CNU. The levels of heptad polymer adducts N7-(2-hydroxyethyl)guanine, (N7-HOEtG); N7-(2-chloroethyl)guanine, (N7-ClEtG); 1,2-[diguan-7-yl]-ethane,
(N7-bis-G); N1-(2-hydroxyethyl)-2-deoxyguanosine, N1-HOEtdG; 1-[N1-2-deoxyguanosinyl], 2-[N3-2-deoxycytidyl]-ethane, dG-dC;
O6-(2-hydroxyethyl)-2-deoxyguanosine, O6-HOEtdG and phosphotriesters (PTE), were quantified in apiece of the radiophone lines mass communication with 3H-CNU. The levels of N…
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