A meta-analysis and systematised analyse of thalidomide for patients with previously unprocessed binary myeloma.

Cancer Treat Rev. 2008 Mar 30;

Authors: Hicks LK, Haynes AE, Reece DE, Walker IR, Herst JA, Meyer RM, Imrie K,

A systematised analyse and meta-analysis was performed to watch the effectualness and morbidness of thalidomide in previously unprocessed patients with myeloma. Medline, Embase, Cochrane Controlled Trials Register, and abstracts from the dweller Society of Hematology and the dweller Society of Clinical Oncology were searched for irregular dominated trials (RCTs) of either stimulation or fix thalidomide in adults with previously unprocessed myeloma. Nine RCTs of stimulation thalidomide, threesome RCTs of fix thalidomide, and digit RCT of stimulation and fix thalidomide were identified, involving a amount of 4144 subjects. When thalidomide was additional to standard, non-transplantation myeloma therapy, coverall activity (OS) reinforced (HR 0.67; 95% CI 0.56-0.81). When thalidomide was presented as fix mass autologous surgery (ASCT), there was a way to reinforced OS (HR 0.61, 95% CI 0.37-1.01); when the exclusive effort which compounded stimulation and fix thalidomide was excluded from this analysis, a momentous activity plus emerged (HR 0.49, 95% CI 0.32-0.74). The qualifying venture of venous thromboembolism (VTE) with stimulation thalidomide was 2.56 (95% CI 1.88-3.49). A meta-analysis of trials/sub-groups administering baritone molecular coefficient polysaccharide (LMWH) as VTE prophylaxis, advisable a persistently accumulated qualifying venture of VTE with stimulation thalidomide (RR 1.54, 95% CI 1.07-2.22). The qualifying venture of VTE was substantially lower, but ease elevated, when thalidomide was presented as fix therapy mass ASCT (RR 1.95, 95% CI 1.15-3.30). In summary, thalidomide appears to meliorate the coverall activity of patients with new diagnosed myeloma both when it is additional to standard, non-transplantation therapy, and when it is presented as fix therapy mass ASCT. However, thalidomide is related with toxicity, specially a significantly accumulated venture of VTE.

PMID: 18381234 [PubMed - as supplied by publisher]

(Source: person Treatment Reviews)

Tags: Acts, ATM, cancer treatment, Led, Maintenance, MRI, NCR, Risk, Toxicity, transplantation