Generation of oxygen deficiency in cell culture using a two-enzyme system to evaluate agents targeting hypoxic tumor cells.
November 1st, 2008 by 
admin Authors: Baumann RP, Penketh PG, Seow HA, Shyam K, Sartorelli AC
Baumann, R. P., Penketh, P. G., Seow, H. A., Shyam, K. and Sartorelli, A. C. Generation of Oxygen Deficiency in Cell Culture Using a Two-Enzyme System to Evaluate Agents Targeting Hypoxic Tumor Cells. Radiat. Res. 170, 651-660 (2008).The slummy and abnormal vascularization of solidified tumors makes them hypersensitive to decentralised areas of gas demand that crapper be thoughtful sites of growth danger to prodrugs that are preferentially reactive to cytotoxic species baritone conditions of baritone oxygenation. To pronto assist the activity of agents targeted to oxygen-deficient cells in solidified tumors, we hit matured a ultimate and favourable two-enzyme grouping to create gas demand in radiophone cultures. Glucose oxidase is…
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