Replication-dependent radiosensitization of human glioma cells by inhibition of poly(adp-ribose) polymerase: mechanisms and therapeutic potential
November 1st, 2008 by 
admin Conclusion: The results of our think hit shown that KU-0059436 increases sensitiveness in a replication-dependent behavior that is enhanced by fractionation. A execution is planned whereby PARP action increases the frequency of collapsed copy forks after ionised radiation, generating continual polymer double-strand breaks. These observations inform that KU-0059436 is probable to compound the therapeutic ratio achieved by irradiation in the communication of glioblastoma multiforme. A Phase I clinical effort is in development. (Source: International Journal of Radiation Oncology * Biology * Physics)
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