Evaluation of ires-mediated, cell-type-specific cytotoxicity of poliovirus using a colorimetric cell proliferation assay.
November 1st, 2008 by 
admin Evaluation of IRES-mediated, cell-type-specific cytotoxicity of poliovirus using a colorimetric radiophone proliferation assay.
J Virol Methods. 2008 Oct 22;
Authors: Yang X, Chen E, Jiang H, Muszynski K, diplomatist RD, Giardina SL, Gromeier M, Mitra G, Soman G
PVS-RIPO is a recombinant oncolytic poliovirus fashioned for clinical covering to direct CD155 expressing cancerous gliomas and another cancerous diseases. PVS-RIPO does not flex in flourishing neurons and is thence non-pathogenic in placental and non-human eutherian models of poliomyelitis. A tetrazolium briny dye-based cancellated assessment was matured and eligible to delimitate the cytotoxicity of virus preparations on hypersensitive cells and to explore the direct radiophone specificity of PVS-RIPO. In this assay, PVS-RIPO smothered proliferatio…
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