Vegf-dependent induction of cd62e on endothelial cells mediates glioma tropism of adult haematopoietic progenitor cells

November 1st, 2008 by admin

Haematopoietic ascendent cells (HPC) are attracted by empiric gliomas in vivo. This magnet is boost enhanced by irradiation or hypoxic preconditioning of the glioma cells. Adhesive interactions strength be grave to the advantageous accruement of HPC within the glioma tissue. Here, we unnatural the interactions of HPC with endothelial cells. Exposure of manlike intellectual endothelial cells (SV-HCEC), manlike microvascular endothelial cells (HMEC) and mentality growth endothelial cells derivative from manlike glioblastomas (BTEC) to supernatants of glioma cells and direct glioma cells (SN-G) evoked the countenance of E-selectin (CD62E). CD62E countenance was boost enhanced when the glioma cells had been unclothed to irradiation or hypoxia preceding to the assemblage of supernatants, as substantially as by i…

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