Evaluation of the antiproliferative state of 2-(monohalogenophenylamino)-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazoles.

Arzneimittelforschung. 2008;58(7):353-7

Authors: Juszczak M, Matysiak J, Brzana W, Niewiadomy A, Rzeski W

Two 2-(monohalogenophenylamino)-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazoles were synthesized by state of sulfinyl bis(2,4-dihydroxythiobenzoyl) with 4-substituted 3-thiosemicarbazides and evaluated for their antiproliferative state in growth cells and for cytotoxicity in connatural cells. Both derivatives in micromolar concentrations induced a striking antiproliferative gist in growth cells derivative from cancers of the troubled grouping (rhabdomyosarcoma/medulloblastoma, glioma) and marginal cancers, including boob carcinoma and lung carcinoma. The antitumor gist was attributed to attenuated polymer reasoning and was not adjoining with necrobiosis induction. Both compounds were not cyanogenic to connatural manlike wound fibroblasts.

PMID: 18751502 [PubMed - in process]

(Source: Arzneimittel-Forschung)

Tags: apoptosis, Breast, Cancer, Concentration, Dna, glioma, Toxicity