Analysis of 11C-methionine Uptake in Low-Grade Gliomas and Correlation with Proliferative Activity.

AJNR Am J Neuroradiol. 2008 Aug 7;

Authors: Kato T, Shinoda J, Oka N, Miwa K, Nakayama N, Yano H, Maruyama T, Muragaki Y, Iwama T

BACKGROUND AND PURPOSE: The relation of (11)C-methionine (MET) uptake and growth state in low-grade gliomas (those gathering the criteria for World Health Organization [WHO] evaluate II gliomas) relic uncertain. The intend of this think was to study MET uptake in low-grade gliomas and to dissect whether MET positron-emission picturing (PET) crapper judge growth viability and wage grounds of cancerous transformation. MATERIALS AND METHODS: We unnatural glioma metabolous state in 49 serial patients with new diagnosed evaluate II gliomas by using MET tomography before preoperative resection. On MET PET, we rhythmic tumor/normal mentality uptake ratio (T/N ratio) in 21 distribute astrocytomas (DAs), 12 oligodendrogliomas (ODs), and 16 oligoastrocytomas (OAs). We compared MET T/N ratio among these 3 tumors and investigated doable reciprocity with proliferative activity, as rhythmic by Mib-1 labeling finger (LI). RESULTS: MET T/N ratios of DA, OD, and OA were 2.11 +/- 0.87, 3.75 +/- 1.43, and 2.76 +/- 1.27, respectively. The MET T/N ratio of OD was significantly higher than that of DA (P < .005). In comparability of MET T/N ratios with the Mib-1 LI, a momentous reciprocity was shown in DA (r = 0.63; P < .005) but not in OD and OA. CONCLUSION: MET uptake in DAs haw be intimately related with growth viability, which depends on accumulated paraffin Elvis instrumentation by an reactive carrier-mediated system. DAs with modify MET uptake were thoughtful more quiescent lesions, whereas DA with higher MET uptake haw behave more aggressively.

PMID: 18687745 [PubMed - as supplied by publisher]

(Source: AJNR Am J Neuroradio…)

Tags: Brain, glioma, Health, NCR, tomography