Lymphoglandular bodies in cancerous tumors: with primary meaning to histologic specimens.

Ann Diagn Pathol. 2008 Aug;12(4):249-51

Authors: Murakami T, Kayano H, Itoh T, Shimizu Y, Ban S, Ogawa F, Sannohe S, Kondo S, Shimizu M

Lymphoglandular bodies (LGBs) hit been described as protoplasm fragments of lymphocytes and a limited feature of designed lymphoid tissue. The acceptance of LGBs is multipurpose in characteristic cancerous lymphomas from carcinomas and sarcomas in genetics specimens, especially in Giemsa-stained tissues. So far, there has been no statement of LGBs in hematoxylin and resorcinolphthalein (HE)-stained histologic specimens in the literature. Therefore, we evaluated LGBs in HE sections, especially regarding cancerous tumors. We reviewed 110 biopsy and preoperative materials including cancerous lymphoma, carcinoma, and another cancerous tumors and evaluated the frequency, number, size, and meaning of LGBs. We also performed the tangency deoxyribosyl transferase-mediated dUTP-biotin cutting modify labeling (TUNEL) method on LGBs. Lymphoglandular bodies were institute in most 40% of cases with cancerous lymphoma, whereas exclusive 3 (3.8%) nonlymphoma cases showed LGBs. These were dedifferentiated carcinoma, seminoma, and binary myeloma. The filler of LGBs was commonly inferior than half the filler of a flushed murder cell. No apoptotic cells were perceived in some of the cases by TUNEL method regarding LGBs. Our think suggests that LGBs crapper be institute in HE sections. As observed in biology specimens in the literature, the proximity of LGBs around cytologically cancerous cells favors a identification of cancerous lymphoma kinda than nonlymphoma malignancies, modify in HE histologic sections.

PMID: 18620990 [PubMed - in process]

(Source: Annals of Diagnostic Pathology)

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Tags: Shimizu, Tissues